Efficient design of magnitude and 2's complement comparators

Digital comparators are important arithmetic components used in digital systems to determine if two numbers are equal, or if one number is greater or less than the other. In this work, the design of magnitude and 2's complement comparators is examined. New OR-based full tree and simplified tree magnitude comparator architectures are proposed. The existing and the proposed comparator architectures are implemented in standard cell technology and evaluated, after extensive experimental analysis, in high performance and relaxed conditions. The proposed comparators operate faster than the existing ones, while operating at the same speed yield significant improvement in area complexity and power dissipation.     

Variable stage-independent double sampling plan with screening for acceptance quality loss limit inspection scheme

The quality loss suggested by Taguchi has been recognised as a new quality evaluation based on variable property instead of the quality evaluation based on traditional attribute property such as the proportion of nonconforming items. Some variable sampling inspection plans in order to assure the quality have been considered. As one of those sampling inspection plans, the single sampling plan with screening (SSPS) has been constructed for acceptance quality loss limit inspection scheme. Further, the repetitive group sampling plan with screening (RGSPS) has been developed for reducing the average total inspection (ATI). Although ATI by RGSPS has successfully been reduced in comparison with ATI by SSPS, RGSPS may sometimes increase the average sampling frequency (ASF) in return for reducing ATI. In this study, the stage-independent double sampling plan with screening (SIDSPS) based on the concept of the acceptance quality loss limit inspection scheme is proposed under the consideration of the trade-off between ATI and ASF. Through some numerical comparisons about ATI and ASF in SSPS, RGSPS, and SIDSPS, the usefulness of SIDSPS proposed in this study is confirmed.     

Anti-Inflammatory Treatment with FTY720 Starting after Onset of Symptoms Reverses Synaptic Deficits in an AD Mouse Model

Therapeutic approaches providing effective medication for Alzheimer’s disease (AD) patients after disease onset are urgently needed. Previous studies in AD mouse models suggested that physical exercise or changed lifestyle can delay AD-related synaptic and memory dysfunctions when treatment started in juvenile animals long before onset of disease symptoms, while a pharmacological treatment that can reverse synaptic and memory deficits in AD mice was thus far not identified. Repurposing food and drug administration (FDA)-approved drugs for treatment of AD is a promising way to reduce the time to bring such medication into clinical practice. The sphingosine-1 phosphate analog fingolimod (FTY720) was approved recently for treatment of multiple sclerosis patients. Here, we addressed whether fingolimod rescues AD-related synaptic deficits and memory dysfunction in an amyloid precursor protein/presenilin-1 (APP/PS1) AD mouse model when medication starts after onset of symptoms (at five months). Male mice received intraperitoneal injections of fingolimod for one to two months starting at five to six months. This treatment rescued spine density as well as long-term potentiation in hippocampal cornu ammonis-1 (CA1) pyramidal neurons, that were both impaired in untreated APP/PS1 animals at six to seven months of age. Immunohistochemical analysis with markers of microgliosis (ionized calcium-binding adapter molecule 1; Iba1) and astrogliosis (glial fibrillary acid protein; GFAP) revealed that our fingolimod treatment regime strongly down regulated neuroinflammation in the hippocampus and neocortex of this AD model. These effects were accompanied by a moderate reduction of Aβ accumulation in hippocampus and neocortex. Our results suggest that fingolimod, when applied after onset of disease symptoms in an APP/PS1 mouse model, rescues synaptic pathology that is believed to underlie memory deficits in AD mice, and that this beneficial effect is mediated via anti-neuroinflammatory actions of the drug on microglia and astrocytes.     

2020年国内外宏观经济形势分析及预判

2020年,预计全球贸易进展局势出现缓和,世界经济增长小幅回升至2.6%左右,主要经济体面临的贸易政策、货币政策和地缘政治局势等不确定性因素仍较多,世界经济增长面临的下行风险仍较大。2019年中国经济总体平稳,GDP增长6.1%。2020年我国经济将继续保持增长稳健、结构优化、动能转换的发展态势,预计将实现6.0%的增长。     

银额盆地路井凹陷下白垩统巴一段储层特征及其影响因素

近年来,银额盆地路井凹陷的油气勘探取得了一些成果,但其勘探程度低且地质条件复杂,储层特征及其影响因素尚不明确。本文从储层岩石学特征着手,运用常规物性分析、岩石薄片及铸体薄片等资料分析了储层特征,从沉积相、压实作用、岩屑组分和粒度等方面探讨了储层的影响因素。巴一段储层岩性主要为岩屑砂岩和长石岩屑砂岩,砂岩多呈粗粒砂状结构,磨圆度差到中等,分选中到差。胶结类型主要为孔隙式胶结,成分成熟度较低。平均孔隙度5.2%,平均渗透率0.58×10^-3μm^2。储层孔隙类型主要有粒间孔和粒间溶孔,次生孔隙构成较主要的储集空间。储集层主要分布在扇三角洲前缘。储层物性随着深度的增加而变差,但局部存在高渗带,可能与酸溶作用有关,随着勘探的进一步深入,需要进一步研究。     

异料拼接对女装毛衫创新设计的影响

针对目前女装毛衫款式简单,缺乏前卫创新设计,难以充分满足毛衫市场时装化、外穿化的需求,结合2019秋冬国际品牌流行发布会上的毛衫设计实例,从点线面的视角阐述异料拼接在女装毛衫上的表现形式,将材料的多元组合思维引入女装毛衫设计,展示了异料拼接在女装毛衫设计中的应用形式及特征,总结出其对毛衫款式、造型、风格、功能4个层面设计的影响,指出在打破传统款式限制、改变毛衫空间廓形、提升毛衫风格美感与功能性等方面具有重要意义,为毛衫产业实现转型升级提出新的参考路径。     

The Regulatory Functionality of Exosomes Derived from hUMSCs in 3D Culture for Alzheimer's Disease Therapy

Reducing amyloid‐β (Aβ) accumulation could be a potential therapeutic approach for Alzheimer's disease (AD). Particular functional biomolecules in exosomes vested by the microenvironment in which the original cells resided can be transferred to recipient cells to improve pathological conditions. However, there are few reports addressing whether exosomes derived from cells cultured on scaffolds with varying dimension can reduce Aβ deposition or ameliorate cognitive decline for AD therapy. Herein, both 3D graphene scaffold and 2D graphene film are used as the matrix for human umbilical cord mesenchymal stem cell culture, from which the supernatants are obtained to isolate exosomes. The levels of 195 kinds of miRNAs and proteins, including neprilysin, insulin‐degrading enzyme and heat shock protein 70, in 3D‐cultured exosomes (3D‐Exo) are dramatically different from those obtained from 2D culture. Hence, 3D‐Exo could up‐regulate the expression of α‐secretase and down‐regulate the β‐secretase to reduce Aβ production in both AD pathology cells and transgenic mice, through their special cargo. With rescuing Aβ pathology, 3D‐Exo exerts enhanced therapeutic effects on ameliorating the memory and cognitive deficits in AD mice. These findings provide a novel clinical application for scaffold materials and functional exosomes derived from stem cells.